Director/senior Director of Statistical Science

Director/Senior Director of Statistical Science - Statistical Innovation

Location: Cambridge or Macclesfield (UK) Gaithersburg, Durham, Waltham, Wilmington (US) Gothenburg (Sweden) Mississauga (Canada) Or Barcelona (Spain)

Description

• Do you have a passion for developing and aiding implementation of innovative statistical approaches and methods in clinical studies? Are you up for the challenge to impact a company that follows the science and turns ideas into life changing medicines? If yes, we welcome you to join AstraZeneca!_

We are recruiting a Statistical Science Director to join our growing Statistical Innovation group. Our main focus is providing statistical methodology support for all phases of clinical development for AZ’s Cardiovascular, Renal & Metabolism and Respiratory & Immunology divisions together with specific targeted support for the Oncology division and the newly acquired Alexion division of AZ which specializes in medicines to treat rare diseases.

Main duties and responsibilities

Joining a team of statistical methodology experts, you will provide key input as you work to find solutions to problems at critical stages in the drug development cycle. This is exciting and technically challenging work in a dynamic and constantly changing landscape. Your key focus will be on producing pragmatic solutions, often within a tight time scale where the emphasis will be to deliver first, then refine and develop your solutions thereafter.

You will contribute to, or lead capability build in more than one of the following statistical areas:

• Design of early and late phase clinical studies: including group sequential and adaptive designs using both frequentist and Bayesian approaches.
• Methods to analyse data collected in real-time, Estimands, Missing Data, Subgroup and Biomarkers.

You will also provide expert consultancy on key issues for fellow statisticians working in our therapeutically aligned statistics groups, as well as medical scientists and other key roles across the business. This will involve leading and participating in strategic activities such as capability build projects, which can directly impact improvements to the way clinical trials are designed and analysed in AstraZeneca. As well as developing and implementing new methodology, interacting with external scientists and regulators, through publications, presentations and cross-industry collaborations. There will also be a focus to proactively identify new areas where Statistical Innovation can contribute, developing collaborative relationships with the external scientific/academic community.

Requirements : Essential

• PhD in Statistics or a related field, followed by extensive experience of independent academic research and/or clinical drug development
• Documented ability of delivering innovative statistical solutions in an applied environment (related to at least two of the following areas or being externally recognized as an expert in at least one of these areas): Design of early and late phase clinical studies: including group sequential and adaptive designs. Analysis of data collected in real-time (e.g. sensor data), Missing data and Estimands, Subgroups and Biomarkers)
• Strong knowledge of programming in R and/or SAS
• High level of competence in global and cross-skilled collaborative working
• Extensive track record of research and methodological development in Statistics, supported by scientific publications in first class statistical journals

Desirable

• Knowledge / research experience in the other areas such as development of statistical methodology related to the analysis and interpretation of safety data, observational studies, meta-analysis, non-linear and mixed effect models.
• Broad awareness of statistical issues against the evolving scientific and regulatory landscape

Why AstraZeneca?

It’s a place to think differently - to find new ways of handling and treating diseases. We are trusted and empowered to explore. Ultimately, it’s more than a job. We know that our work impacts people with serious conditions, many of whom have no other alternatives. That’s what drives us - the potential to impact over one billion patients worldwide.

Where can I find out more?

DataAI